Most Home Runs In 2025. Since 2000, albert pujols hit the most home runs, with 703 home runs. Career hr leaders:1.jamie moyer/522/502, 2.robin roberts+/505/1784, 3.fergie jenkins+/484/1010, 4.phil niekro+/482/1707, 5.don sutton+/472/1559, 6.frank.

The official source for player hitting stats, mlb home run leaders, batting average, ops and stat leaders Includes stat leaders in every category from home runs and batting average to strikeouts and saves.